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Year : 2020  |  Volume : 9  |  Issue : 1  |  Page : 88-93

Baseline Vitamin D as a predictor of mortality among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in an endemically Vitamin D-deficient area in North India

1 SDH Sopore, Srinagar, Jammu and Kashmir, India
2 GMC, Baramulla, Jammu and Kashmir, India
3 GMC, Srinagar, Jammu and Kashmir, India

Correspondence Address:
Dr. Mir Nadeem
C/O Dr Mir Waseem, Doctors' Quarters, GMC, Baramulla, Kantbagh, Baramulla - 193 101, Jammu and Kashmir
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijrc.ijrc_48_19

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Background: Conflicting data suggest that Vitamin D reduces the risk of developing chronic obstructive pulmonary disease (COPD) and COPD exacerbations. Scant data are available regarding the Vitamin D status in patients with COPD in India where Vitamin D deficiency is rampant. Objectives: We set out to study the role of baseline Vitamin D on the outcome of acute exacerbation of COPD (AECOPD) in terms of exacerbations, hospitalizations, and mortality. Materials and Methods: In a prospective observational design, 147 consenting participants with AECOPD were recruited and serum Vitamin D assessed at admission. The patients were followed for 3 months for treatment outcomes in terms of mortality, readmissions and exacerbations. Standard statistical methods were used to compare the results among those with sufficient and insufficient Vitamin D status at baseline. Results: Out of 147 completely followed participants, 113 (76.9%) were deficient in Vitamin D (mean ± standard deviation = 11.79 ± 8.5 [normal 30–100 ng/ml]). Patients with low Vitamin D were found to have a significantly higher 90-day mortality than those with normal Vitamin D status (P = 0.42; hazard ratio 4.8, P = 0.032). No statistically significant differences were observed in rates of exacerbations or hospital admission. Conclusion: Patients of AECOPD having baseline Vitamin D deficiency at admission have a higher mortality than those with normal Vitamin D level. Thus, Vitamin D level can serve as a prognostic indicator of the outcome of AECOPD. Larger studies are suggested to further study the association and also determine any role of Vitamin D in the treatment of such cases.

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