|Year : 2020 | Volume
| Issue : 1 | Page : 12-19
Acute respiratory distress syndrome in pregnancy and peripartum: Facts and figures
Nissar Shaikh, Abdulgafoor M Tharayil, Arshad H Chanda, Adel E Ahmed Ganaw, Muhammad Shakeeel Riaz, Stefan Alfred Hubertus Rohrig, Marcus Lance
Department of Anesthesia/ICU and Perioperative Medicine, SICU, Hamad Medical Corporation, Doha, Qatar
|Date of Submission||16-Jul-2019|
|Date of Decision||21-Dec-2019|
|Date of Acceptance||27-Dec-2019|
|Date of Web Publication||08-Jan-2020|
Dr. Abdulgafoor M Tharayil
Hamad Medical Corporation, Doha
Source of Support: None, Conflict of Interest: None
Acute respiratory distress syndrome (ARDS) is a serious condition occurring rarely during pregnancy and peripartum period. ARDS occurs either due to pregnancy associated risk factors or due to the increased risk during pregnancy. Clinical presentation, arterial blood gas, chest X-ray, and computerized tomography will help in the diagnosis of ARDS. Management of ARDS in pregnancy and peripartum period can be summarized by the “ARDS12,” including lung protective ventilation (lower tidal volume, higher respiratory rate, positive end expiratory pressure titration), negative fluid balance, neuromuscular blocking agents, prone position, use of inhaled nitric oxide, high frequency oscillation ventilation, extracorporeal membrane oxygenation, extracorporeal carbon dioxide removal, use of corticosteroids and continuing the supportive care. Overall morality from ARDS is showing decreasing trends, and the mortality during pregnancy and peripartum period is significantly lower than in general population.
Keywords: Acute respiratory distress syndrome, arterial blood gas, chest X-ray, excluding cardiogenic pulmonary edema, extracorporeal membrane oxygenation, neuromuscular blocking agents, peripartum, pregnancy, steroids
|How to cite this article:|
Shaikh N, Tharayil AM, Chanda AH, Ahmed Ganaw AE, Riaz MS, Hubertus Rohrig SA, Lance M. Acute respiratory distress syndrome in pregnancy and peripartum: Facts and figures. Indian J Respir Care 2020;9:12-9
|How to cite this URL:|
Shaikh N, Tharayil AM, Chanda AH, Ahmed Ganaw AE, Riaz MS, Hubertus Rohrig SA, Lance M. Acute respiratory distress syndrome in pregnancy and peripartum: Facts and figures. Indian J Respir Care [serial online] 2020 [cited 2020 Jan 26];9:12-9. Available from: http://www.ijrconline.org/text.asp?2020/9/1/12/275379
| Introduction|| |
Acute respiratory distress syndrome (ARDS) is one of the critical illnesses of pregnancy and peripartum period. It is noncardiogenic pulmonary edema caused by the capillary leak and resulting in increased total lung water. Around 2% of patients require intensive care unit (ICU) admission during pregnancy or in the peripartum period (100–200 ICU admissions in 10,000 deliveries). Majority of the patients present with bleeding and hypertensive disorders of pregnancy. Mostly, these admissions are in the postpartum period. Fortunately, only 0.1%–0.2% of pregnant patients may have acute respiratory failure or ARDS necessitating invasive mechanical ventilation. These patients are at risk from many conditions specific to pregnancy or other preexisting diseases which can complicate into acute respiratory failure. Maternal hypoxemia and hypercapnia will pose significant risk for both mother and the fetus. In the major ARDS trials, pregnancy is a prominent exclusion criterion, hence the management of pregnant patients with ARDS depends mainly on clinical experience or from the case reports. In this review, we will discuss ARDS in pregnancy and peripartum period in the following headings.
- Physiological changes in pregnancy
- Etiology of acute respiratory failure and ARDS in pregnancy and peripartum period
- Definition and Diagnosis of ARDS in pregnancy
- Management of ARDS in pregnancy
- Outcome of ARDS in pregnancy.
| Physiological Changes in Pregnancy|| |
Pregnancy is associated with many physiological adaptations in the mother to meet increased demands by the mother and fetus. [Table 1] summarizes respiratory changes in pregnancy.
Anatomical and functional changes in the maternal respiratory system and additional fetal requirements lead to increased PaO2(100–110 mmHg), 20%–33% increased O2 consumption, 30%–45% increase in cardiac output, increased tidal volume and minute ventilation, decreased PaCO2(27–34 mmHg), chronic respiratory alkalosis (pH 7.4–7.45), reduced serum bicarbonate (18–21 mmol/L), reduced functional residual capacity and decreased chest wall compliance. In summary, pregnant patients have decreased oxygen reserves while the oxygen demands are increased.
| Foetal Oxygen Delivery and Determinants of Uterine Oxygen Delivery|| |
Maternal delivery of oxygen through the placenta to the fetus occurs through the intervillous space of chorionic plate to the fetal umbilical vein, which results in placental transfer of oxygen [Figure 1]. The fetal hemoglobin contains two gamma subunits instead of beta subunits as in adult hemoglobin. This prevents the binding of 2, 3-DPG, which results in a left-shifted oxyhemoglobin dissociation curve, favoring oxygen loading at a low PaO2. carbon dioxide (CO2) is unloaded from the umbilical artery to the uterine vein, as the PaCO2 in fetal.
Umbilical artery is greater than the PaCO2 of maternal uterine vein., Double Bohr and double Haldane effects play an important role in the fetomaternal transfer of oxygen and CO2.
There is a 20-fold rise in uterine artery blood flow during pregnancy, which is the greatest physiological change experienced during the human lifespan. The determinants of uterine oxygen delivery are the maternal PaO2, hemoglobin concentration and saturation, alkalosis causing leftward shift of oxyhemoglobin dissociation curve which increases O2 affinity and decreases O2 transfer, uterine artery blood flow, cardiac output, hypotension and/or increased endogenous or exogenous sympathetic stimulation.
| Etiology of Acute Respiratory Failure and Acute Respiratory Distress Syndrome in Pregnancy and Peripartum|| |
The pregnant patients are predisposed to ARDS by various mechanisms, including increased blood volume, decreased serum albumin level, upregulation of components of acute inflammatory response and increased capillary leak. The etiological factors could be pregnancy associated, increased risk due to pregnancy, not related to pregnancy or nonspecific etiological factors [Table 2].
|Table 2: Aetiology of acute respiratory failure and acute respiratory distress syndrome in pregnancy and peripartum period|
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| Pregnancy Associated Factors|| |
At the onset of labor or with rupture of the ovular membranes, bacteria from the lower genital tract could ascend into the amniotic cavity. This ascending route is the most common pathway for development of intra-amniotic infection. Although it is the common cause for sepsis in peripartum period, it rarely complicates into ARDS.
Abruptio placentae is the separation of normally implanted placenta after 20 weeks of gestation and before birth of fetus. It is frequently associated with massive blood and blood product transfusion and may lead to ARDS.
Amniotic fluid embolism
Occurs in around 7/100,000 pregnancies, it is commonly associated with labour and delivery or may occur following manipulation of uterus. It is frequently manifested by severe dyspnea and hypoxemia, convulsions, and in extreme cases cardiovascular collapse and cardiac arrest. The amniotic fluid embolism patients rescued from the initial event may develop disseminated intravascular coagulation and ARDS. The risk factors for amniotic fluid embolism are advanced maternal age, multiparity, previous caesarean section, laceration of low uterine segment and meconium stained amniotic fluid.
| Increased Risk in Pregnancy|| |
Transfusion related acute lung injury
Pregnant patients due to various etiological reasons are at the risk of hemorrhage in antepartum, partum and postpartum period, requiring massive transfusion of blood and blood products and this leads to transfusion related acute lung injury (TRALI). TRALI is pathologically a noncardiogenic pulmonary edema previously known as “transfused ARDS” because of the same pathognomonic features indistinguishable from ARDS, but associated with plasma transfusion.
The risk of acute pulmonary embolism (PE) is increased five-to six-times during pregnancy. This appears to be a consequence of several factors, including changes in the clotting factors and an increased likelihood of venous stasis. Predisposing factors include obesity, older age, and a personal or family history of thromboembolic disease, inherited thrombophilia, anti-phospholipid syndrome, trauma, caesarean delivery, and immobility.
Asthma and its exacerbation
Asthma is prevalent among 4%–8% of pregnant patients, and 20%–36% of them have an exacerbation during their pregnancy.
Community-acquired pneumonia is a common cause of acute respiratory failure in pregnant patients. Most common pathogens are same as those found in nonpregnant patients, mainly streptococcus pneumoniae, hemophilus influenza, mycoplasma pneumoniae, legionella, chlamydia pneumoniae, and influenza A. Reduction in cell-mediated immunity associated with pregnancy (particularly during the third trimester) also predisposes women to higher risk for severe pneumonia and disseminated disease from atypical pathogens, such as herpes virus, varicella, and coccidioidomycosis.
Aspiration of gastric contents is common during labor or immediate postpartum period. It may be the effects of sedation, analgesia, increased intra-abdominal pressure. The risk factors include increased intra-abdominal pressure, relaxation of the lower esophageal sphincter, and delayed gastric emptying.
Incidence of sepsis in pregnancy varies between 0.1% and 0.3%, risk factors being advanced maternal age, obesity, insulin-dependent diabetes mellitus, multiple pregnancies, invasive diagnostic or therapeutic interventions. Dysfunctional intrinsic defense mechanisms in preterm labor can predispose the mother to sepsis. Incidence of peripartum sepsis is 3 times higher in preterm deliveries than in full term deliveries. Intra-amniotic infection is a significant predisposing factor for development of maternal sepsis. Postpartum sepsis is reported to be 3 times more common after the lower segment caesarean section than after the vaginal delivery.
| Conditions Causing Acute Respiratory Distress Syndrome in Pregnancy|| |
Acute pancreatitis in pregnancy is a common problem, the annual incidence of acute pancreatitis in pregnancy ranges from 1 in 1000 to 1 in 10,000, more frequent in 3rd trimester. The risk factors are advancing gestational age and frequency of gallstones in pregnancy. Principally acute pancreatitis has a good prognosis in pregnancy and peripartum, rarely causing ARDS  as per a 5-year observational study by Vishnupriya et al. among pregnant patients in a tertiary hospital in India.
Most common traumatic injuries are assaults, motor vehicle accidents, falls, and partner abuse. Trauma complicates 1 in 12 pregnancies but 9 out of 10 traumatic injuries during pregnancy are fortunately minor injuries.
Acute chest syndrome
Pregnancy can be associated with sickle cell disease and those patients are at risk of developing acute chest syndrome which presents with acute respiratory failure. It can progress to ARDS. [Table 2] depicts the various risk factors associated with the development of acute respiratory failure and ARDS in pregnant patients.
| Definition and Diagnosis|| |
The ARDS definition was refined in 2012 [Table 3]. History of primary pathology or increased risk are important factors in developing ARDS in pregnancy and peri-partum period. The respiratory symptoms may be confused with changes of pregnancy. Presence of fever should raise the suspicion of infection particularly when combined with inflammatory markers such as increased white cell count, C reactive protein or procalcitonin. An arterial blood gas (ABG) and chest X-ray should be performed, which demonstrates hypoxia and diffuse bilateral infiltrates [Figure 2] respectively. Both are the essential components for the diagnosis of ARDS [Table 3]. Computerized tomography (CT) chest if performed, will show more details of lung involvement [Figure 3] though it is not recommended or needed to establish the diagnosis or grading of ARDS. [Table 3] shows the comparison between American European Consensus definition and the Berlin definition. [Figure 2] shows the typical findings in chest X-ray of ARDS patients and [Figure 3] shows the CT chest findings in ARDS patients. Advanced imaging studies should be done only if diagnosis is difficult, considering the risk of radiation to mother and fetus. [Table 4] shows the radiation hazard with various imaging techniques. Advanced investigations such as proBNP, cardiac troponin, transthoracic or transoesophageal echocardiogram are helpful in differentiating from cardiogenic pulmonary edema.
|Figure 3: Computerized tomography chest showing bilateral patchy consolidations|
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| Management|| |
Initially the standard management of respiratory distress irrespective of the cause of the ARDS should be in place. A reasonable goal for pregnant patients would be to maintain the oxygen saturation >95% to optimize the fetal oxygen content. Adequate fetal oxygenation requires a maternal arterial oxygen tension (PaO2) >70 mmHg. When the ARDS patients require mechanical ventilation, their management may be complicated by difficult intubation during pregnancy and peripartum period because of the upper airway edema, narrowed airway caliber which may necessitate the presence of adequate difficult airway equipment. Another important factor is that the pregnant patients have hypocapnia due to hyperventilation. Hence their arterial CO2 tension (PaCO2) tends to be lower than in nonpregnant individuals and ventilator setting should be set up accordingly.
In general, the ARDS management includes 12 parameters [Table 5].
| Standardized Mechanical Ventilation|| |
Generally mechanical ventilation should be optimized to prevent volutrauma, barotrauma, biotrauma, and atelectrauma. Lung protective strategies, should be followed which include lower tidal volume (6 ml/kg), increasing the respiratory rate to get a reasonable minute ventilation appropriate for the physiological changes in pregnancy as much as possible. Adjust or increase the positive end expiratory pressure (PEEP) and decrease the fraction of inspired oxygen (FiO2) by following the PEEP: FiO2 table. Permissive hypercapnia with a pH of ≥7.25 should be acceptable though the physiology of pregnancy demands mild alkalosis. Plateau pressure should be kept ≤30 cm H2O. More recently, driving pressure (plateau pressure-PEEP) is considered to be more important than tidal volume and plateau pressure and worth monitoring. The driving pressure in ARDS patients is directly and independently associated with mortality. Despite the advantages of monitoring and controlling driving pressure in ARDS patients, it does not reflect the true transpulmonary driving pressure which is more precisely correlated with ventilator induced lung injury in obese patients and patients with high intraabdominal pressure. Recruitment maneuvers were initially recommended to open the lungs and higher PEEP to keep it open, but a recent meta-analysis showed that it might increase mortality and decrease ventilator free days and higher incidence of barotrauma.
Special considerations in pregnant patients include aiming for a higher SpO2 as adequate foetal oxygenation requires a PaO2 of 70 mmHg, which corresponds to a maternal SpO2 of about 95%, a lower PaCO2 target of 30–32 with mild respiratory alkalosis to resemble maternal physiology  and a higher PEEP to mitigate the atelectasis induced by gravid uterus. However, a very low PaCO2 can affect the uterine blood flow and should be avoided.
| Negative Fluid Balance|| |
It is commonly said in the critical care practice that “the dry lungs are happy lungs.” As the pathological change in ARDS is the fluid accumulation in the interstitial tissues of the lung, by restricting fluid intake and keeping the fluid balance negative, patients will benefit from decreased lung water content. Though the fluid and catheter treatment trial had not shown any beneficial effect on mortality with the conservative fluid therapy, it resulted in more days free from mechanical ventilation and ICU stay.
| Neuromuscular Blocking Agents|| |
Neuromuscular blocking agents (NMBA) might improve the mechanical viscoelastic properties of the chest wall. Abolition in spontaneous ventilatory activity increases the total thoracopulmonary compliance because of the improved ventilator patient synchrony and a decrease in the expiratory muscular activity, which will have an oxygen sparing effects as well. However, prolonged use of NMBA particularly in combination with steroid will increase the chances of critical illness neuromuscular abnormality. ACURASYS study showed the beneficial effect of the early use of NMBA in ARDS patients. However a recently published randomised trial called ROSE trial by the National Heart, Lung and Blood Institute PETAL Clinical Trials Network found no meaningful improvement in mortality with neuromuscular blocking agent and light sedation without NMBA. Unfortunately, this study was unblinded with significant patients lost at screening because they received a NMBA before randomization. Moreover, depth of neuromuscular block was not monitored (apparently to mimic ACURASYS trial) but in contrast to ACURASYS trial, light sedation was used in this trial which could have increased oxygen consumption.
| Prone Positioning in Pregnancy|| |
Ventilation in prone position improves oxygenation in all the patients by reopening the posterior dependent consolidated areas of the ARDS lungs. Up to 60% of patients show improvement in oxygenation after prone ventilation. Prone positioning to improve oxygenation in ARDS patients has been known since late 70's, but its use in clinical practice was not significantly common, till the Proning Severe ARDS Patients trial showed a survival benefit. Proning was once considered risky in pregnant patients for the concern of foetal well-being. Hence, there are few case reports of prone position successfully used in patients with ARDS., Samanta et al. used prone positioning as a rescue therapy for their pregnant patient who failed to oxygenate adequately with 100% oxygen. The authors used large rollers underneath chest and iliac crest and used cardiac tocography (CTG) to monitor foetal well-being. Proning is not free from complications, and utmost precautions are essential. Apart from usual care, pregnant patients require extra precautions to avoid any external abdominal pressure. Chest and hips should be significantly elevated than in nonpregnant patients to avoid compression of the abdomen. In addition, the face and particularly the eyes should be protected. Continuous foetal monitoring with CTG is a requirement and needs trained and dedicated supporting staff. A good team work is the key for success.
| Inhaled Vasodilators|| |
Although inhaled nitric oxide (iNO) improves oxygenation modestly, a recent Cochrane systematic review could not show improvement of morbidity or mortality The Food and Drug Administration has not approved the use of inhalational iNO during pregnancy. Moreover, it is not known whether iNO can cause fetal harm, or whether NO is excreted in human milk. In contrast it increases the risk of renal impairment. So, this therapy cannot be recommended for the general management of ARDS in pregnancy. Not much of the literature is available about other inhaled vasodilators uses in pregnancy and peripartum in ARDS patients.
High frequency oscillation
High-frequency ventilation is a form of mechanical ventilation that uses the lung protective benefits of very low tidal volumes less than anatomical dead space combined with very high respiratory rates (>60 breaths/min). Although theoretically this sounds good, the strategy could not show improved mortality in ARDS patients.
Extracorporeal membrane oxygenation
Sharma and colleagues reported cases of extra corporeal life support during pregnancy and postpartum period, published between 2009 and 2014. They reported that the overall maternal survival as 80% and fetal survival as 70%.
However, Nair et al. reported that extracorporeal membrane oxygenation (ECMO) in pregnancy was technically challenging, bleeding was common leading to large volumes of blood transfusion which contributed largely to the mortality. Moore et al. presented their results of ECMO during pregnancy and concluded that ECMO is effective and relatively safe for the mother and fetus. In their study the authors found that ECMO during pregnancy had a maternal survival rates of 77.8% and perinatal survival of 65.1% which is in line with the results from Sharma et al.
Extracorporeal carbon dioxide removal
This is a relatively upcoming new technology, which mainly targets the removal of CO2 only. In that sense the application of this technique will be of limited value as the ARDS is mainly a hypoxic disease. However, literature about its application during pregnancy is limited to some case reports only.
Steroids in ARDS have been used by clinicians in 3 different situations: prevention of ARDS in high risk patients, early treatment of ARDS with high-dose and short-course therapy, or prolonged therapy in un-resolving ARDS. There is no evidence to support the routine use of corticosteroids for the prevention of ARDS in high risk patients while their use has beneficial effect in un-resolving ARDS cases as per earlier studies. A recent consensus paper by multispecialty task force of 16 international experts in critical care medicine, endocrinology, guideline methods, recommends the use of systemic corticosteroids in moderate to severe ARDS within 14 days of onset. These principles should be applicable to pregnant patients with ARDS as well. However, there is no specific trial in this population.
It is of vital importance to continue supportive care apart from ARDS management alone. Other supportive care means interventions that sustain life and prevent complications, but do not treat the underlying cause of the critical illness. It includes sedation, pain control, hemodynamic support (vasopressors), monitoring of vital signs, adequate volume management, nutritional support, stress ulcer prophylaxis, and venous thromboembolism prophylaxis.
The overall mortality in nonpregnant patients from severe ARDS is showing a decreasing trend which is directly mainly driven by improved strategies in mechanical ventilation with the limitation of driving pressures in particular.
However, mortality of severe ARDS in pregnancy is comparatively lower and reported to be 9%, and the risk factors are prolonged ventilation, renal failure requiring dialysis, liver failure, amniotic fluid embolism, influenza and septic obstetric emboli.
| Summary|| |
ARDS is one of the critical illnesses of pregnancy and peripartum period. It is noncardiogenic pulmonary edema caused by the capillary leak and resulting in increased total lung water. ARDS in pregnancy and peripartum period can be caused by the pregnancy related conditions such as amniotic fluid embolism, hypertensive disorders of pregnancy or other conditions such as pneumonia, PE and sepsis.
In combination with the clinical parameters, ABG and imaging studies are needed to confirm the diagnosis of ARDS excluding the cardiogenic pulmonary oedema using advanced hemodynamic monitoring or echocardiography.
In the management of ARDS it is of vital importance to have optimized ventilator strategies with the limitation and control of the plateau pressure and accepting a higher partial pressure of CO2. To achieve this goal, proning of these patients and extracorporeal oxygenation are accepted methods. In contrast high frequency oscillation is out of practice as it showed limited benefit. Pharmacologically, early course of muscle relaxant might have beneficial effect on oxygenation for selected group of patients while steroid therapy remains controversial and inhalational therapy might even harm.
Finally, supportive care such as ulcer prophylaxis, nutrition, and deep venous thrombosis prophylaxis are important for the basic management.
The overall ARDS mortality in pregnancy and peripartum period is lesser than the general population and prolonged ventilation, amniotic fluid embolism and organ failure increases the risk of death in ARDS patient in pregnancy and peripartum period.
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Conflicts of interest
There are no conflicts of interest.
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[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]