|Year : 2019 | Volume
| Issue : 2 | Page : 134-135
Pleural mesothelioma with peritoneal involvement: Diagnosed on 18F-FDG positron emission tomography/computed tomography
Anuja Anand, Farhan Siddique, Jaspriya Bal, Madhavi Chawla, Pankaj Dougall
Department of Nuclear Medicine and PET-CT, Max Superspeciality Hospital, Saket, New Delhi, India
|Date of Submission||04-Jan-2019|
|Date of Decision||25-Feb-2019|
|Date of Acceptance||20-Apr-2019|
|Date of Web Publication||1-Jul-2019|
Dr. Anuja Anand
Department of Nuclear Medicine and PET-CT, Max Superspeciality Hospital, Saket, New Delhi
Source of Support: None, Conflict of Interest: None
Pleural mesothelioma with metastatic peritoneal involvement is an extremely rare finding. Very few cases are reported in the literature. We present a case of pleural mesothelioma referred for F-18-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT). There was extension of pleural thickening into the omentum and peritoneum. This case demonstrates the role of F-18-fluorodeoxyglucose PET/CT in detecting other sites of involvement in case of malignant mesothelioma.
Keywords: Malignant mesothelioma, pleuroperitoneal mesothelioma, positron emission tomography/computed tomography
|How to cite this article:|
Anand A, Siddique F, Bal J, Chawla M, Dougall P. Pleural mesothelioma with peritoneal involvement: Diagnosed on 18F-FDG positron emission tomography/computed tomography. Indian J Respir Care 2019;8:134-5
|How to cite this URL:|
Anand A, Siddique F, Bal J, Chawla M, Dougall P. Pleural mesothelioma with peritoneal involvement: Diagnosed on 18F-FDG positron emission tomography/computed tomography. Indian J Respir Care [serial online] 2019 [cited 2020 Jan 25];8:134-5. Available from: http://www.ijrconline.org/text.asp?2019/8/2/134/261893
A 77-year-old-male presented with a history of asbestos exposure and histologically proven malignant pleural mesothelioma. The patient was referred for 2-(fluorine-18) fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG PET/CT) for initial disease assessment which revealed extensive FDG avid irregular mass-like thickening involving right parietal and visceral pleura, leading to collapse of the underlying lung [Figure 1]. Along with that, FDG avid diffuse peritoneal and mesenteric thickening was noted [Figure 1]. Histopathology from the peritoneal thickening was not done due to poor patient compliance; however, due to extensive right pleural disease and increased FDG uptake in the peritoneum, the diagnosis of benign peritoneal involvement is less likely and of mesothelioma involvement is more likely. Malignant mesothelioma is a rare malignancy which originates from the cells lining the mesothelial surfaces, such as pleura, peritoneum, pericardium, and tunica vaginalis. The pleural form being the most common subtype, however, peritoneal mesothelioma was the first to be described by Miller and Wynn (1908). The malignant peritoneal mesothelioma constitutes 12.5%–25% of all malignant mesotheliomas. Mostly, it occurs in middle-aged men who commonly present with the complaints of abdominal pain or a feeling of fullness, abdominal distention or increasing abdominal girth, nausea, anorexia, and weight loss. FDG PET for the diagnosis of malignant pleural malignancy (MPM) has been finding increasing use recently. The principle is that the increased glucose metabolism of the tumor cells helps to identify malignancy at PET. The standardized uptake value (SUV), which is a semiquantitative measure of the metabolic activity of a lesion, is significantly increased in MPM than in benign pleural diseases such as inflammatory pleuritis and asbestos-related pleural thickening., PET-CT provides both anatomic and metabolic information about a lesion. The sensitivity of FDG PET/CT is higher for detecting lymph node and distant metastases, thereby helps in staging. Furthermore, higher SUV in FDG PET/CT is associated with poor prognosis. FDG PET/CT also has higher accuracy for treatment response evaluation in malignant mesothelioma. Our case also emphasizes that FDG PET/CT plays an important role in detecting the extent of the disease by detection of pleural as well as peritoneal lesion more so because it is a whole-body scan which has an advantage of PET over CT alone. Thus, 18F-FDG PET/CT is of great importance in the evaluation and management of malignant mesothelioma.
|Figure 1: (a) Maximum intensity projection image showing fluorodeoxyglucose avid right pleural thickening along with fluorodeoxyglucose uptake in peritoneum, predominantly toward the right side of pelvic cavity. (b and c) Axial images showing fluorodeoxyglucose avid nodular thickening along costal, mediastinal, and diaphragmatic pleura. (d) Axial image of pelvis showing extensive peritoneal and mesenteric involvement|
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Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient has given his consent for his images and other clinical information to be reported in the journal. The patient understands that his name and initials will not be published and due efforts will be made to conceal his identity, but anonymity cannot be guaranteed.
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Conflicts of interest
There are no conflicts of interest.
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