• Users Online: 348
  • Print this page
  • Email this page
Year : 2019  |  Volume : 8  |  Issue : 2  |  Page : 130-133

Acute onset of refractory hypoxemia: Arare hemodynamic cause of dyspnea

Department of Medicine, Medical High Dependency Unit, Ospedale Niguarda Ca' Granda, Milano, MI, Italy

Correspondence Address:
Dr. Tommaso Valobra
Ospedale Niguarda Ca' Granda, Piazza dell'Ospedale Maggiore, 3, 20162 Milano, MI
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijrc.ijrc_2_19

Rights and Permissions

Platypnea-orthodeoxia syndrome(POS) is a rare condition of positional dyspnea with hypoxemia that can pose a diagnostic challenge to clinicians. We report two cases of POS with different pathophysiologic triggers and similar clinical features. In our report, both patients manifested a severe hypoxemia with low response to increase of fractional inspired oxygen, unremarkable physical examination of the lungs, and no radiological findings of the pulmonary embolism. In both cases, an interatrial communication was found in association with a right-to-left interatrial shunting. Recognition of POS is crucial because symptoms can be quickly relieved by recumbency, unlike other types of hypoxemia. This simple solution may prevent the use of sedative therapy, invasive ventilatory support, and vasopressor agents, which could even exacerbate the right-to-left extrapulmonary shunt and worsen clinical conditions.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded59    
    Comments [Add]    

Recommend this journal