ORIGINAL ARTICLE
Year : 2014  |  Volume : 3  |  Issue : 2  |  Page : 449-454

Comparative evaluation of the effect of magnesium sulphate with lignocaine on the haemodynamic response to orotracheal intubation


1 Ex-Postgraduate in Anaesthesiology, Kasturba Medical College, Manipal University, Manipal, India
2 Ex-Additional Professor, Department of Anaesthesiology, Kasturba Medical College, Manipal University, Manipal, India
3 Professor, Department of Anaesthesiology, Kasturba Medical College, Manipal University, Manipal, India
4 Ex-Associate Professor, Department of Anaesthesiology, Kasturba Medical College, Manipal University, Manipal, India

Correspondence Address:
Swati Verma
Ex-Postgraduate in Anaesthesiology, Kasturba Medical College, Manipal University, Manipal
India
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Source of Support: None, Conflict of Interest: None


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Introduction: Magnesium sulphate inhibits the release of catecholamines from adrenal medulla whereas lignocaine blocks conduction of nerve impulses. Both these drugs may suppress adverse haemodynamic responses to laryngoscopy and intubation. Aim: The purpose of the study was to evaluate the effect and safety of an intravenous bolus dose of 2% lignocaine (1.5 mg/kg) or 50%magnesium sulphate (40 mg/kg) on the haemodynamic response to laryngoscopy and intubation in anaesthetised and paralysed adults. Patients and Methods: This was a prospective, randomised, double-blind study. Sixty four adults, belonging to ASA PS 1 and 2, were randomised to one of two groups: Group M and Group L. Heart rate, systolic, diastolic and mean arterial blood pressures were recorded every minute from injection of study drug upto 5 minutes post-intubation. Serum magnesium levels were measured before and after giving magnesium in Group M patients. Results: Heart rate was significantly higher and diastolic blood pressure significantly lower at 30 seconds in magnesium group whereas systolic and mean arterial pressures were comparable in both groups at all time intervals. Total muscle relaxation time was highly significant in magnesium group as compared to lignocaine. Post-study magnesium levels in Group M were statistically significant but not clinically significant as all values were within normal therapeutic range. Conclusion: Intravenous bolus dose of magnesium sulphate (40 mg/kg) can be used safely as a substitute for lignocaine for attenuation of haemodynamic responses to laryngoscopy and orotracheal intubation.


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